My PhD research focused on the application of quadruplexes within genes involved in drug resistance mechanisms to restore the efficacy of antibiotics in multi-drug resistant pathogens. This has vast implications for combating antimicrobial resistance (AMR), often seen as one of the top existential threats to humankind.
Quadruplex DNA, DNA cloning, Protein expression and purification, SPR, ELISA, Flow cytometry, NGS analysis, PCR.
Antimicrobial Resistance, Bacteria, Cell culture.
Antibody discovery, Lead seeking, Assay development, In vitro.
Senior Research Associate
Zoetis Cambridge (Previously PetMedix), UK
I support the development of antibody discovery programs targeted at companion animals, carrying out in vitro screening and functionality assays. My role involves day to day generation, maintenance and usage of cell lines for cell-based assays, functionality screening of antibodies and developing in-house protocols.
Notable outputs:
Associate Lecturer
Anglia Ruskin University & Open University, UK
Tutoring undergraduate students of the life sciences/biomedical science discipline at different levels both online and F2F. Facilitating practical sessions relating to microbiology, bioinformatics, cancer biology and diagnostic techniques.
Research Assistant
Centre for Human Virology and Genomics, NIMR, Nigeria
Over 500 patient sample analyses weekly for HIV, Hepatitis C and Hepatitis B. Investigated HCV rapid test kits as a certified tester for a FIND (Foundation for Innovative New Diagnostics) project.
PhD Biomedical Science
Anglia Ruskin University, UK
Investigations introducing an assembled quadruplex DNA in the combinational treatment of A. baumannii revealed a significant decrease in resistance to a carbapenem antibiotic in vitro, indicating the ability to restore the efficacy of available antibiotics in the treatment of microbial infections.
Bioinformatic analysis of quadruplex structures to evaluate the probability of structural assembly by a predicted quadruplex-forming sequence. Applied biophysical structural characterisation techniques on secondary nucleotide structures.
Notable outputs:
MSc Applied Biosciences
Anglia Ruskin University, UK
The presence of sequences with the ability to form quadruplex structures within the efflux pump gene adeABC of the multidrug resistant A. baumannii proffers their potential role in the resistance mechanism of the pathogen.
BSc Physiology
University of Ibadan, Nigeria
Studied the differential effects of total and partial sleep deprivation on salivary factors in Wistar rats. Publication